IL-2

By Type:	Pan (8) Selective (5)
By Effects:	Inhibitors (15) Activator (1) Modulators (2) Inducer (1)

Cat. No.	Product Name	Effect	Purity

HY-P9926

Dupilumab	Inhibitor	≥99.2%
Dupilumab (REGN-668) is a fully human mAb to IL-4 receptor α (IL-4Rα) that inhibits both IL-4 and IL-13 signaling, markedly improved moderate-to-severe atopic dermatitis.

HY-N6607

Tryptanthrin	Modulator	99.89%
Tryptanthrin is an indole quinazoline that could be an alkaloid from indigo-bearing plants. Tryptanthrin is a potent and orally active cellular Leukotriene (LT) biosynthesis inhibitor. Tryptanthrin has anticancer activity. Tryptanthrin suppresses the expression levels of NOS1, COX-2, and NF-κB and regulates the expression levels of IL-2, IL-10, and TNF-α.

HY-108738

Daclizumab	Inhibitor
Daclizumab (Zenapax) is a humanized, monoclonal antibody that blocks CD25 (α-subunit of the high-affinity interleukin-2 receptor (IL-2R-HA)). Daclizumab (Zenapax) reversibly binds to CD25and prevents the interaction of IL-2 with the IL-2R-HA. Daclizumab (Zenapax) can be used for multiple sclerosis research.

HY-113618B

RO2959 monohydrochloride	Inhibitor	98.21%
RO2959 monohydrochloride is a potent and selective CRAC channel inhibitor with an IC₅₀ of 402 nM. RO2959 monohydrochloride is a potent blocker of store operated calcium entry (SOCE) mediated by Orai1/Stim1 channels with an IC₅₀ of 25 nM. RO2959 monohydrochloride is also a potent inhibitor of human IL-2 production, and potently blocks T cell receptor triggered gene expression and T cell functional pathways.

HY-N0600

Ginsenoside F3	Modulator	99.84%
Ginsenoside F3, a component of PPTGs (an minor saponin in the leaves of Panax ginseng), has immunoenhancing activity by regulating production and gene expression of type 1 cytokines (IL-2, IFN-gamma) and type 2 cytokines (IL-4 and IL-10).

HY-119424

SP4206	Inhibitor	98.55%
SP4206 is an IL-2/IL-2Rα interaction inhibitor. SP4206 binds with high affinity (K_d=70 nM) to IL-2 and blocks binding to its natural receptor IL-2Rα (K_d=10 nM).

HY-17002

Suplatast (Tosilate)	Inhibitor	98.33%
Suplatast Tosilate (IPD 1151T) is an orally active Th2 cytokine inhibitor which can inhibit both IL-4 and IL-5 production from Th2 cells and suppress IgE synthesis. Suplatast Tosilate is an anti-allergic agent. Suplatast Tosilate has antiasthmatic, anti-inflammatory and antifibrotic activity.

HY-N0594

Deacetylasperulosidic Acid	Inhibitor	99.86%
Deacetylasperulosidic acid (DAA) is a major phytochemical constituent of Morinda citrifolia fruit. Deacetylasperulosidic acidhas antioxidant activity by increasing superoxide dismutase activity. Deacetylasperulosidic acid has anticlastogenic activity, suppressing the induction of chromosome aberrations in hamster ovary cells and mice. Deacetylasperulosidic acid prevents 4-nitroquinoline 1-oxide (4NQO) induced DNA damage in vitro, suppresses IL-2 production along with the activation of natural killer cells.

HY-100176

PF-4878691		99.89%
PF-4878691 (3M-852A) is an orally active TLR7 agonist. PF-4878691 has the innate immune response activity, antiviral efficacy against HCV, and can be used for the research of cancer.

HY-21293

SU5201	Inhibitor	99.45%
SU5201 is an inhibitor of interleukin-2 (IL-2) production.

HY-113618A

RO2959 hydrochloride	Inhibitor
RO2959 hydrochloride is a potent and selective CRAC channel inhibitor with an IC₅₀ of 402 nM. RO2959 hydrochloride is a potent blocker of store operated calcium entry (SOCE) mediated by Orai1/Stim1 channels with an IC₅₀ of 25 nM. RO2959 hydrochloride is also a potent inhibitor of human IL-2 production, and potently blocks T cell receptor triggered gene expression and T cell functional pathways.

HY-106087

IX 207-887	Inhibitor	98.96%
IX 207-887 is a novel antiarthritic agent which inhibits the release of interleukin-1 (IL-1).

HY-150051

IL-2-IN-1	Inhibitor	99.95%
IL-2-IN-1 is a potent IL-2 inhibitor with an IC₅₀ value of 1978 nM. IL-2-IN-1 shows antiproliferative activities.

HY-112778

NFAT Transcription Factor Regulator-1	Inhibitor	99.37%
NFAT Transcription Factor Regulator-1 is an IL-2 synthesis inhibitor with an IC₅₀ of 182 nM.

HY-P990086

Vopikitug	Inhibitor
Vopikitug is an IgG1-kappa, anti-IL2RA (interleukin 2 receptor alpha subunit, IL-2RA, TAC, p55, CD25) homo sapiens monoclonal antibody. Vopikitug shows antineoplastic activity.

HY-112335

Lck Inhibitor III	Inhibitor
Lck Inhibitor III (compound 12h) is a potent Lck inhibitor, with an IC₅₀ of 867 nM. Lck Inhibitor III inhibits IL-2 synthesis in Jurkat cells, with an IC₅₀ of 1.270 μM.

HY-117843

Ppc-1	Inhibitor
Ppc-1 is a mitochondrial uncoupler. Ppc-1 enhances mitochondrial oxygen consumption without adverse effects on ATP production. Ppc-1 is a cell-permeate interleukin-2 (IL-2) inhibitor. Ppc-1 inhibits the Gram-negative periodontopathogen *Porphyromonas gingivalis*. Ppc-1 has anti-obesity, antibacterial and anti-inflammatory activities.

HY-P3736

Myelopeptide-2	Inducer
Myelopeptide-2 is a peptide originally isolated from the supernatant of porcine bone marrow cell cultures, can restore mitogenic reactivity of human T lymphocytes inhibited by HL-60 leukemia cells or measles virus conditions. Myelopeptide-2 also recover depressed interleukin-2 (IL-2) synthesis and interleukin-2 receptor (IL-2R) expression. Myelopeptide-2 involves in immunity homeostasis, is perspective to be applied in antitumor and antivirus research.

HY-153952

Immuno modulator-1	Inhibitor
Immuno modulator-1 (compound 22) inhibits TNFα and IL-2 secretion in human peripheral blood mononuclear cells (hPBMC), with IC₅₀ values of 4.7 and 26 nM, respectively. Immuno modulator-1 shows hERG potassium channel blocking effect, with Inhibitory percentage of 20% at 3 μM.

HY-161335

HPK1-IN-43	Activator
HPK1-IN-43 (compound 9f) is a HPK1 kinase inhibitor with the IC₅₀ value of 0.32 nM. HPK1-IN-43 inhibits the phosphorylation of the downstream protein SLP-76 and enhances the secretion of interleukin-2 (IL-2) and interferon-γ (IFN-γ). HPK1-IN-43 can be used in cancer research.

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